Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2005-08-23
2010-11-23
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S311000, C544S317000, C514S269000
Reexamination Certificate
active
07838675
ABSTRACT:
A compound of formula (1), or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof and pharmaceutical compositions comprising these, all for use in the treatment of chemokine mediated diseases and disorders.
REFERENCES:
patent: 2540356 (1951-02-01), Sprague
patent: 3082206 (1963-03-01), Langley
patent: 3132139 (1964-05-01), Bretshneider et al.
patent: 3452018 (1969-06-01), Santilli et al.
patent: 3457278 (1969-07-01), Zimmermann
patent: 3673184 (1972-06-01), Minami et al.
patent: 1042295 (1966-09-01), None
patent: 61-118372 (1986-05-01), None
patent: 03-197467 (1991-08-01), None
patent: WO 91/15209 (1991-10-01), None
patent: WO 97/22596 (1997-06-01), None
patent: WO 97/30035 (1997-08-01), None
patent: WO 97/32856 (1997-09-01), None
patent: WO 98/13354 (1998-04-01), None
patent: WO 99/02166 (1999-01-01), None
patent: WO 99/41253 (1999-08-01), None
patent: WO 00/09511 (2000-02-01), None
patent: WO 00/40529 (2000-07-01), None
patent: WO 00/41669 (2000-07-01), None
patent: WO 00/76980 (2000-12-01), None
patent: WO 01/25242 (2001-04-01), None
patent: WO 01/58902 (2001-08-01), None
patent: WO 01/58906 (2001-08-01), None
patent: WO 01/92224 (2001-12-01), None
patent: WO 02/04434 (2002-01-01), None
patent: WO 02/08213 (2002-01-01), None
patent: WO 02/24665 (2002-03-01), None
patent: WO 02/064096 (2002-08-01), None
patent: WO 03/059893 (2003-07-01), None
patent: WO 2004/011443 (2004-02-01), None
patent: WO 2004/018435 (2004-03-01), None
Spiteller et al., Monatshefte fuer Chemie (1961), 92, 183-92; CA 55:131336, 1961. CAPLUS Abstract provided.
Budesinsky et al., Cesko-Slovenska Farmacie (1961), 10, 241-7 ; CA 55:137544, 1961. CAPLUS Abstract provided.
Ueda et al., JP 37004894 ;CA 59:85806,1963. CAPLUS Abstract provided.
Domori et al., Yakugaku Zasshi (1967), 87(4), 419-29; CA 67:90760,1967. CAPLUS Abstract provided.
Budesinsky et al., CS 159015 ; CA 84:105637, 1976. CAPLUS Abstract provided.
Grigoryan et al., Grigoryan, L. A.; Armyanskii Khimicheskii Zhurnal (1987), 40(7), 443-7; CA 108:131739, 1988. CAPLUS Abstract provided.
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
Raman et al., “Role of chemokines in tumor growth”,Cancer Letters256:137-165 (2007).
Rosténe et al., “Chemokines: a new class of neuromodulator?”,Nature Reviews Neuroscience8:895-904 (2007).
Banker et al., “Prodrugs”, Modern Pharmaceutics, 3rded., Marcel Dekker, New York, pp. 451 & 596 (1996).
Bremner et al., “Therapy of Crohn's Disease in childhood”,Expert Opin. Pharmacother. 3(7):809-825 (2002).
Bundgaard, Design of prodrugs, p. 1 (1985).
Cobo et al., “Reactivity of 6-Aminopyrimidin-4-(3H)-ones Towards Dimethyl Acetylenedicarboxylate (DMAD). Tandem Diels-Alder/Retro Diels-Alder (DA/RDA) Reaction in the Synthesis of 2-Aminopyridines”,Tetrahedron50(34):10345-10358 (1994).
Havlioglu et al., “Slit proteins, potential endogenous modulators of inflammation”,J NeuroVirology8:486-495 (2002).
Hübsch and Pfleiderer, “Synthesis and Properties of 8-Substituted 2-Thiolumazines”,Helvetica Chimica Acta71:1379-1391 (1988).
Inoue et al., “Preparation of 2-(alkylthio)-6-amino-5-(trifluoromethyl)-4(3H)-pyrimidinone derivatives as insecticides, acaricides, or agrochemical fungicides”, CAPLUS Abstract 115:280054 (1991).
Inoue et al., “2-(Alkylthio)-6-amino-3(2H)-pyrimidinones”, CAPLUS Abstract 106:18604 (1987).
Lee et al., “Characterization of Two High Affinity Human Interleukin-8 Receptors”,J. Biol. Chem. 267(23):16283-16287 (1992).
Merritt et al., “Use of fluo-3 to measure cytosolic Ca2+in platelets and neutrophils. Loading cells with the dye, calibration of traces, measurements in the presence of plasma, and buffering of cytosolic Ca2+”,Biochem. J.269:513-519 (1990).
Noell and Robins, “Aromaticity in Heterocyclic Systems. II. The Application of N.M.R. in a Study of the Synthesis and Structure of Certain Imidazo[1,2-c]Pyrimidines and Related Pyrrolo[2,3-d]Pyrimidines”, Department of Chemistry, Arizona State University vol. 1: 34-41 (1964).
Nogimori et al., “Synthesis of 6-Anilino-2-thiouracils and Their Inhibition of Human Placenta Iodothyronine Deiodinase”, J. Med. Chem. 28:1692-1694 (1985).
Robinson, “Medical Therapy of Inflammatory Bowel Disease for the 21st Century”,Eur J Surg Suppl582:90-98 (1998).
Rodriguez et al., “Aminopyrimidines and Derivatives.20. on the Acetylations of 5-Amino-4-Glycosylamino Pyrimidines”,Nucleosides&Nucleotides6(5):887-899 (1987).
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thed., vol. 1, pp. 1004-1010 (1996).
Singh et al., “Immune therapy in inflammatory bowel disease and models of colitis”,British Journal of Surgery88:1558-1569 (2001).
Ulrich, Crystallization: 4. Crystal Characteristics, Kirk-Othmer Encyclopedia of Chemical Technology, Aug. 2002.
Vinkers et al., “Synopsis: SYNthesize and OPtimize System in Silico”,J. Med. Chem.46:2765-2773 (2003).
Vippagunta et al., “Crystalline solids”,Advanced Drug Delivery Reviews48:3-26 (2001).
West, “Solid State Chemistry and its Applications”, Wiley, New York, pp. 358 & 365 (1988).
Wolff, “Some considerations for prodrug design”, Burger's Medicinal Chemistry and Drug Discovery, 5thed., vol. I: Principles and Practice, John Wiley & Sons, pp. 975-977 (1995).
Zambeli and Kolbah, “Acetylation of some 2-(alkyl)thio-4-amino-6-hydroxy-pyrimidines”,Acta Pharm. Jug.21:91-96 (1971).
Cheshire David Ranulf
Cox Rhona Jane
Meghani Premji
Stonehouse Jeffrey Paul
AstraZeneca AB
Balasubramanian Venkataraman
Fish & Richardson P.C.
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