Pyrimidine nucleoside derivatives having anti-tumor activity, th

Details Pyrimidine nucleoside derivatives having anti-tumor activity, th Pyrimidine nucleoside derivatives having anti-tumor activity, th

1995-06-05

1997-11-25

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2851, 536 284, 536 281, 536 221, A61K 31505, A61K 3170, C07H 1909

Patent

active

056913192

ABSTRACT:
Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.

REFERENCES:
patent: 4211773 (1980-07-01), Lopez et al.
patent: 4818750 (1989-04-01), Rideout et al.
Ho et al, Cancer Res. 37:1640-1643 (1977).
Martin et al, J. Pharm. Sci. 76(2): 180-184 (1987).
Wechter et al., J. Med. Chem. 18(4): 339-344 (1975).
Baker et al, J. Med. Chem. 21(12): 1218-1221 (1978).
Baker et al, J. Med. Chem. 22(3): 273-279 (1979).
Matsuda et al (1991) J. Med. Chem, 34, 2917-2919.
Matsuda et al (1990) Nucleic Acids Symp. Ser. 22, 51-52 (Abstract).
Hibich et al (1988) Synthesis, 12, 943-47.
Greengrass et al (1989) J. Med. Chem, 32, 618-23.
Matsuda et al (1990) Nucleic Acid Research Ser. 22, 51-52.
Camarada et al (1989) J. Med. Chem. 132, 1732-38.

Affiliated with

Also associated with

Rating

Pyrimidine nucleoside derivatives having anti-tumor activity, th does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrimidine nucleoside derivatives having anti-tumor activity, th, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidine nucleoside derivatives having anti-tumor activity, th will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2107198