Pyrimidine nucleoside derivatives and salts thereof

Details Pyrimidine nucleoside derivatives and salts thereof Pyrimidine nucleoside derivatives and salts thereof

2007-02-15

2011-12-13

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S274000, C536S027400, C544S309000, C544S311000, C544S312000, C544S314000

Reexamination Certificate

active

08076302

ABSTRACT:
A novel pyrimidine nucleoside derivative represented by the following formula (1) and a salt thereof, as well as a pharmaceutical composition comprising the same as an active ingredient have excellent antiviral properties and are useful as antiviral therapeutic agents:[wherein R represents a nitrogen-containing heterocyclic ring which may have any one of a C1-C3alkyl group or a C1-C3alkoxy group as a substituent, or a C1-C6alkyl group which has one primary amino group as a substituent].

REFERENCES:
patent: 4386076 (1983-05-01), Machida et al.
patent: 4542210 (1985-09-01), Sakata et al.
patent: 5446031 (1995-08-01), Sakata et al.
patent: 31128 (1981-07-01), None
patent: 74101 (1983-03-01), None
patent: 572669 (1993-12-01), None
patent: 56-87599 (1981-07-01), None
patent: 58-43993 (1983-03-01), None
patent: 4-505920 (1992-10-01), None
patent: WO 90/15064 (1990-12-01), None
patent: WO 92/19638 (1992-11-01), None
Razonable et al., PubMed Abstract (Herpes 10(3):60-5), Dec. 2003.
Douglas, Jr. Introduction to Viral Diseases, Cecil Textbook of Medicine, 20thEdition, vol. 2, pp. 1739-1747, 1996.
Goff, PubMed Abstract (J Gene Med. 3(6):517-28) Nov.-Dec. 2001.
Bosseray et al., PubMed Abstract (Pathol. Biol. 50(8):483-92), Oct. 2002.
Kano, F. et al., 5′-O-alkyl and acyl prodrugs of 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl) uracil, Antiviral Chemistry & Chemotherapy, 1994, vol. 5, No. 2, pp. 74-82.
Ashida, Noriyuki et al., Metabolism of 5′-ether prodrugs of 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl) uracil in rats, Biochemical Pharmacology, 1993, vol. 46, No. 12, pp. 2201-2207.
Reefschlaeger, J. et al., Antiherpes activity of (E)-5-(2-bromovinyl)- and 5-vinyl-1-β-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines, Antiviral Research, 1983, vol. 3, No. 3, pp. 175-187.
Machida, H. et al., In vitro anti-herpesvirus activities of 5-substituted 2′-deoxy-2′ methylidene pyrimidine nucleosides, Antiviral Chemistry & Chemotherapy, 1993, vol. 4, No. 1, pp. 11-17.
Yu, Chung-Shan et al., Synthesis of (E)-5-(2-radio-iodovinyl) arabinosyl uridine analog for probing HSV-1 thymidine kinase gene, Chemistry Letters, 2005, vol. 34, No. 10, pp. 1390-1391.
Yu, Chung-Shan et al., Syntheses of 5-fluoro and (E)-5-(2-fluorovinyl) arabinosyl uridine analogues as potential probes for the HSV-1 thymidine kinase gene, Synthesis, 2006, No. 22, pp. 3835-3840.
Kulikowski, T. et al., Pyrimidine arabinofuranosyl nucleosides with 5-substituted long, branched and unsaturated chains: synthesis and antiherpes properties, Nucleic Acids Symposium Series, 1981, vol. 9, pp. 103-106.

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