Pyrimidine derivatives useful as inhibitors of PKC-theta

Details Pyrimidine derivatives useful as inhibitors of PKC-theta Pyrimidine derivatives useful as inhibitors of PKC-theta

2005-07-06

2009-10-13

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S255050, C514S275000, C544S122000, C544S295000, C544S323000, C544S324000

Reexamination Certificate

active

07601714

ABSTRACT:
Disclosed are novel compounds of formula (I):wherein X, Y, R1, R2and R3are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

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