Pyrimidine derivatives, processes for preparation thereof and co

Details Pyrimidine derivatives, processes for preparation thereof and co Pyrimidine derivatives, processes for preparation thereof and co

1985-07-11

1987-10-06

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514235, 514256, 544 60, 544122, 544242, 544295, 544333, 544335, 544 584, A61K 31505, C07D23926

Patent

active

046983406

ABSTRACT:
The invention relates to pyrimidine derivatives and their pharmaceutically acceptable salts which are useful in the treatment of cerebrovascular diseases, to processes for preparation thereof and to the composition containing the same, said pyrimidine derivatives being represented by the following formula: ##STR1## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are as defined in the disclosure.

REFERENCES:
patent: 3969355 (1976-07-01), Schwan
patent: 4382140 (1983-05-01), Schwan
Menichi et al, Chemical Abstracts, vol. 74, (1971), 125626t.
J. Heterocyclic Chem., 18, 183 (1981); E. J. Breaux et al, An Improved General Synthesis of 4-Aryl-5-Pyrimidinecarboxylates, Jan. 1981.
Arch. Pharm. (Weinheim) 314, 938-949 (1981); Klaus Gorlitzer et al, 2,4-Diaryl-6-Methyl-1,2,3,4-Tetrahydropyrimidine-5-Carbonsaureester.
Arch. Pharm. (Weinheim)312, 591-597(1979); Fritz Eiden et al, Uber die Reaktion von 2,6-Dimethyl-4-Pyron-3,5-Dicarbonsaureethylester Mit Aminen.

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