Pyrimidine derivatives for the treatment of abnormal cell...

Details Pyrimidine derivatives for the treatment of abnormal cell... Pyrimidine derivatives for the treatment of abnormal cell...

2008-07-29

2010-06-22

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S323000, C544S324000

Reexamination Certificate

active

07741336

ABSTRACT:
The present invention relates to a compound of the formula 1wherein R1-R4are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

REFERENCES:
patent: 4507146 (1985-03-01), Tobler
patent: 4983608 (1991-01-01), Effland
patent: 5521184 (1996-05-01), Zimmermann
patent: 5753663 (1998-05-01), Flippin
patent: 5863924 (1999-01-01), Berger
patent: 6134510 (2000-10-01), Deco et al.
patent: 6297258 (2001-10-01), Wissner
patent: 6600037 (2003-07-01), Davis et al.
patent: 7109335 (2006-09-01), Kath et al.
patent: 7109337 (2006-09-01), Kath et al.
patent: 7122670 (2006-10-01), Kath et al.
patent: 7145008 (2006-12-01), Kath et al.
patent: 7173028 (2007-02-01), Dahmann et al.
patent: 7208499 (2007-04-01), Kath et al.
patent: 7235561 (2007-06-01), Brumby et al.
patent: 7235562 (2007-06-01), Kath et al.
patent: 7291624 (2007-11-01), Brumby et al.
patent: 7351712 (2008-04-01), Kath et al.
patent: 2003/0134838 (2003-07-01), Bomemann et al.
patent: 2003/0162802 (2003-08-01), Guo
patent: 2003/0171359 (2003-09-01), Dahmann
patent: 2003/0181474 (2003-09-01), Peace
patent: 2008/0300234 (2008-12-01), Kath et al.
patent: 4029650 (1992-03-01), None
patent: 533016 (1992-09-01), None
patent: 542079 (1992-11-01), None
patent: 0 553 016 (1997-05-01), None
patent: WO93/10086 (1993-05-01), None
patent: WO93/24467 (1993-12-01), None
patent: WO97/12880 (1997-04-01), None
patent: WO97/19065 (1997-05-01), None
patent: WO98/05661 (1998-02-01), None
patent: WO98/09961 (1998-03-01), None
patent: WO98/32079 (1998-07-01), None
patent: WO 98/37079 (1998-08-01), None
patent: WO99/09016 (1999-02-01), None
patent: WO99/41253 (1999-08-01), None
patent: WO00/12485 (2000-03-01), None
patent: WO00/18740 (2000-04-01), None
patent: WO00/39101 (2000-07-01), None
patent: WO01/21597 (2001-03-01), None
patent: WO01/60816 (2001-08-01), None
patent: WO01/68186 (2001-09-01), None
patent: WO01/72744 (2001-10-01), None
patent: WO02/08193 (2002-01-01), None
patent: W02/16352 (2002-02-01), None
patent: WO02/12227 (2002-02-01), None
patent: WO02/12228 (2002-02-01), None
patent: WO02/16348 (2002-02-01), None
patent: WO02/20501 (2002-03-01), None
patent: WO02/059110 (2002-08-01), None
patent: WO02/096887 (2002-12-01), None
patent: WO02/096888 (2002-12-01), None
patent: WO03/018021 (2003-03-01), None
patent: WO03/020276 (2003-03-01), None
patent: WO03/030909 (2003-04-01), None
patent: WO03/032997 (2003-04-01), None
patent: WO03/063794 (2003-08-01), None
patent: WO03/066565 (2003-08-01), None
patent: WO03/066575 (2003-08-01), None
patent: WO03/078404 (2003-09-01), None
patent: WO03/095448 (2003-11-01), None
patent: WO2004/046118 (2004-06-01), None
patent: WO 2004/056786 (2004-07-01), None
patent: WO2004/056788 (2004-07-01), None
patent: WO2004/056807 (2004-07-01), None
patent: WO2005/111022 (2005-11-01), None
Cecil Textbook of Medicine, edited by Bennet, J.C., and Plum F., 20th edition,vol. 1, 1004-1010, 1996.
Freshney et al.,Culture of Animal Cells, A Manual of Basic Technique, Alan R. Liss, Inc., 1983, New York, p. 4.
Dermer et al., Bio/Technology, 1994, 12:320.
Powell et al., British Journal of Dermatology, 141: 802-810, 1999.
Cohen et al., Current Opinion in Chemical Biology, 3,459-465, 1999.
Golub et al., Science, 286, 531-537, 1999.
Mass, R. D., Int. J. Radiation Oncology Bio. Phys.vol. 58(3): 932-940, 2004.
Fabbro et al. Pharmacology & Therapeutics 93, 79-98, 2002.
Bramson, H. Neal et al., Oxindole-Based Inhibitors of Cyclin-Dependent Kinases 2 (CDK2); Design, Synthesis, Enzymatic Activities and X-ray Crystallographic Analysis,Journal of Medicinal Chemistry(2001), 44-(25), 4339-4358, XP002274118.
Diringer et al., Journal of Medicinal Chemistry, vol. 13, No. 1, pp. 151-152 (1970).
Kath, J., “Patent Focus: Inhibitors of Tumour Cell Growth,”Expert Opinion on Therapeutic Patents,Ashley Publications, GB, vol. 10, No. 6, 2000, pp. 803-818, XP000919385, Issn: 1354-3776.
Knockaert, Marie et al., “Identifying in vivo targets of cyclin-dependent kinase inhibitors by affinity chromatography,”Biochemical Pharmacology(2002), 64(5-6), 819-825, XP002274117.
Stever, D. et al., “Recent Advances in Protein Kinases Inhibitors: Current Molecular Scaffolds Used for Inhibitor Synthesis,”Current Opinion in Drug Discovery and Development, Current Drugs,London, GB, vol. 2, No. 4, 1999, pp. 274-285, Issn: 1367-6733.
Supuran et al., Expert Opin. Ther. Patents, vol. 14, No. 1, pp. 35-53 (2004).
Sep. 11, 2009 Response to Non-Final Office Action in connection with U.S. Appl. No. 12/059,889.
Sep. 18, 2009 Examiner Interview Summary in connection with U.S. Appl. No. 12/059,889.
Oct. 19, 2009 Applicant Interview Statement in connection with U.S. Appl. No. 12/059,889.
Oct. 21, 2009 Notice of Allowance in connection with U.S. Appl. No. 12/059,889.

Affiliated with

Also associated with

Rating

Pyrimidine derivatives for the treatment of abnormal cell... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrimidine derivatives for the treatment of abnormal cell..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrimidine derivatives for the treatment of abnormal cell... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4210248