Pyrimidine derivatives as alk-5 inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S326000, C544S333000

Reexamination Certificate

active

07989458

ABSTRACT:
Compounds of formula (I) in free or salt or solvate form, where T1, T2, Raand Rbhave the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

REFERENCES:
patent: WO 02/47690 (2002-06-01), None
patent: WO 2004/065392 (2004-08-01), None
patent: WO 2004/111036 (2004-12-01), None
patent: WO 2005/058883 (2005-06-01), None
Vippagunta SR, Brittain HG, and Grant D J, “Crystalline solids,” Advanced Drug Delivery Reviews, May 2001,48(1), 3-26.

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