Pyrimidine derivatives and composition of the same

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514211, 514222, 514265, 540485, 544 584, 544 586, 544 60, 544122, 544295, 544242, 544335, A61K 31505, C07D40304

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active

047270730

ABSTRACT:
The invention relates to new pyrimidine derivatives, useful in the treatment of cerebrovascular disease, of the formula: ##STR1## wherein Ar, R.sup.1, R.sup.2 and R.sup.3 are defined in the specification.

REFERENCES:
patent: 3944581 (1976-03-01), Schwan
patent: 4382140 (1983-05-01), Schwan
J. Heterocyclic Chem., 18, 183(1981); E. J. Breaux et al., An Improved General Synthesis of 4-Aryl-5-pyrimidinecarboxylates, Jan. 1981.
Arch. Pharm. (Weinheim) 314, 938-949, (1981); Klaus Gorlitzer et al., 2,4-Diaryl-6-methyl-1,2,3,4-tetrahydropyrimidin-5-carbonsaureester.
Arch. Pharm. (Weinheim) 312, 591-597, (1979); Fritz Eiden et al., Uber die Reaktion von 2,6-Dimethyl-4-pyron-3,5-dicarbonsaureethylester mit Aminen.

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