Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-05-06
1982-07-27
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544253, 544262, 544292, 544330, 544332, A61K 31505, C07D23942
Patent
active
043417825
ABSTRACT:
Novel pyrimidine derivatives of the formula; ##STR1## ps wherein Ar is phenyl or naphthyl, which may be substituted by lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, halogen, nitro, trifluoromethyl or di-lower alkylamino; R.sup.1 is lower alkyl, lower cycloalkyl, trifluoromethyl, lower alkoxycarbonyl, phenyl or benzyl, and the phenyl may be substituted by halogen; R.sup.2 is hydrogen or lower alkyl; R.sup.3, R.sup.4 and R.sup.5 are hydrogen,lower alkyl, lower alkenyl or lower alkoxy, or R.sup.3 and R.sup.4 or R.sup.4 and R.sup.5 combine with each other to represent trimethylene, tetramethylene or butadienylene, or salts of them, are excellent antimicrobial agents.
REFERENCES:
Claesen et al., Bull. Soc. Chim. Belg. 68, pp. 47-58, 1959.
Brown, The Pyrimidines Supplement I, pp. 22-23, pub. by Wiley-Interscience (1970).
Konishi Kazuo
Matsuura Kazuho
Coughlan, Jr. Paul M.
Takeda Chemical Industries Ltd.
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