"Pyrimidine derivatives"

Details "Pyrimidine derivatives" "Pyrimidine derivatives"

1989-12-15

1991-09-24

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23922

Patent

active

050514296

ABSTRACT:
Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. Also novel methods of manufacture for the derivatives, pharmaceutical compositions thereof, and methods of use therefor are the invention.

REFERENCES:
patent: 4780537 (1988-10-01), Vedrs et al.
Noell et al., J. Med. Pharm. Chem., vol. 5, pp. 558-588c (1962).
Discussion at 16th Annual Graduate Student Meeting in Med. Chem. at U. of M., Ann Arbor, Mich. "8 Amino-9-Benzylguanine" Bio Chem. Pharm., 31, 163-171, (1982).
J. Am. Chem. Soc. 81, 3046-3051 (1959).
J. Het. Chem., 21, 1245-6 (1984).
Heterocycles, vol. 22, No. 8, 1984, pp. 1789-1790.
Heterocycles, vol. 22, No. 11, 1984, pp. 2439-2441.

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