Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1987-07-30
1989-11-21
Lilling, Herbert J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 50, 536 23, A61K 3170, C07H 1907, C07D40504, C07D40300
Patent
active
048823163
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is halogen, C.sub.1-4 -alkyl or halo-(C.sub.1-4 - alkyl), R.sup.2 is hydrogen, hydroxy or acyloxy, R.sup.3 and R.sup.4 each are hydrogen or C.sub.1-4 -alkyl, R.sup.5 is aryl or aryloxy, X is O or NH and Y is --CO--CH.sub.2 --, --CH(OH)--CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --S--, --SO-- or --SO.sub.2 --,
and tautomers thereof are described. Compounds of formula I and their tautomers possess antiviral activity and can be used in the form of medicaments for the control and prevention of viral infections.
REFERENCES:
patent: 4000260 (1976-12-01), Prusoff et al.
Elliott et al. "Jour. Medicinal Chem." 1981 vol. 24 #3; pgs. 350-352.
Hampton et al., J. of Med. Chem., vol. 22, No. 12, pp. 1524-1528 (1979).
Setsuro et al., The Chemical Abstracts, 86: 16907n (1977).
Montgomery et al., The Chemical Abstracts 100: 156925z (1984).
Markham et al., Antiviral Research No. 2, pp. 319-330 (1982).
Lambert Robert W.
Martin Joseph A.
Thomas Gareth J.
Boxer Matthew
Hoffmann-La Roche Inc.
Leon Bernard S.
Lilling Herbert J.
Saxe Jon S.
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