Pyrimidine derivative condensed with a non-aromatic ring

Details Pyrimidine derivative condensed with a non-aromatic ring Pyrimidine derivative condensed with a non-aromatic ring

2011-05-24

2011-05-24

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S278000, C544S280000, C544S279000, C544S253000, C514S252160, C514S264100, C514S265100, C514S266100, C514S266220, C514S258100

Reexamination Certificate

active

07947690

ABSTRACT:
The present invention provides a condensed pyrimidine compound represented by formula (I) or pharmaceutically acceptable salt thereof:where A represents a ringwhere at least one carbon atom within said ring is optionally substituted with one or more groups selected from the group consisting of lower alkyl, —O-(lower alkyl), halogen atom, carboxyl, —CO2-(lower alkyl), and carbamoyl, R1represents: (1) phenyl substituted with at least three halogen atoms, which may have at least one additional substituent, or (2) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl, each of which is optionally substituted; and R2represents a group represented by formula (II) or an optionally substituted cyclic amino:wherein R21and R22may be identical or different and each represents —H, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, phenyl, heteroaryl, non-aromatic heterocyclyl, or —O-(lower alkyl), each of which is optionally substituted.

REFERENCES:
patent: 3272811 (1966-09-01), Ohnacker et al.
patent: 4871739 (1989-10-01), Baldwin et al.
patent: 4889856 (1989-12-01), Tolman et al.
patent: 6627628 (2003-09-01), Schindler et al.
patent: 6660746 (2003-12-01), Schindler et al.
patent: 2003/0199526 (2003-10-01), Choquette et al.
patent: 2005/0004143 (2005-01-01), Dugar et al.
patent: 2005/0187217 (2005-08-01), Wilson et al.
patent: 2006/0229306 (2006-10-01), Terricabras Belart et al.
patent: 0 276 057 (1988-07-01), None
patent: 4-224580 (1992-08-01), None
patent: 2004-509115 (2004-03-01), None
patent: WO 00/31047 (2000-06-01), None
patent: WO 00/46214 (2000-08-01), None
patent: WO 02/22605 (2002-03-01), None
patent: WO 03/049739 (2003-06-01), None
patent: WO 2004/065391 (2004-08-01), None
patent: WO 2004/087056 (2004-10-01), None
patent: WO 2005/014558 (2005-02-01), None
“The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus”, The New England Journal of Medicine, vol. 329, No. 14, Sep. 30, 1993, pp. 977-986.
“Glucose Tolerance and Mortality: Comparison of Who and American Diabetic Association Diagnostic Criteria”, The Lancet, vol. 354, 1999, pp. 617-621.
Irene M. Stratton, et al. “Association of Glycaemia With Macrovascular and Microvascular Complications of Type 2 Diabetes (UKPDS 35): Prospective Observational Study”, British Medical Journal, vol. 321, Aug. 12, 2000, pp. 405-413.
Augusto C. Tome, et al. “New Pyrimidine and Pyrimidone Derivatives of [60] Fullerene”, Tetrahedron, vol. 54, 1998, pp. 11141-11150.
Augusto C. Tome, et al. “Pyrimidine and Pyrimidone Derivatives of [60] Fullerene”, Tetrahedron Letters, vol. 38, No. 14, 1997, pp. 2557-2560.
Sachio Ohno, et al., “Synthesis and Hypoglycemic Activity of 7,8-Dihydro-6H-thiopyrano[3,2-d]pyrimidine Derivatives and Related Compounds”, Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, vol. 34, No. 10, XP 000196068, Oct. 1, 1986, pp. 4150-4165.

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