Pyrimidine compounds as purine receptor antagonist

Details Pyrimidine compounds as purine receptor antagonist Pyrimidine compounds as purine receptor antagonist

2011-01-25

2011-01-25

Fetterolf, Brandon J (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S242000

Reexamination Certificate

active

07875600

ABSTRACT:
Compounds of formula (I); wherein R1is H or NHZ; R2is optionally substituted aryl or heteroaryl attached via a carbon atom; R3is H; optionally substituted C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, or C3C7cycloalkyl, halogen; OH or OR, or R4is H, optionally substituted C1-C6alkyl, C3C6alkenyl, C3-C6alkynyl, C3-C7cycloalkyl, aryl or heteroaryl, R5is H or optionally substituted C1-C6alkyl, C3-C6alkenyl, C3-C6alkynyl, or C3-C7cycloalkyl; or R4and R5together form a 5 or 6-membered heterocyclic ring; and R10is optionally substituted C1-C6alkyl; are purine receptor, particularly adenosine receptor antagonists, useful for treatment of, inter alia, movement disorders such as Parkinsons disease.

REFERENCES:
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patent: WO 2004/029204 (2004-04-01), None
patent: WO 2004/080979 (2004-09-01), None
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Obrecht D et al: “5. A Novel and Officient Approach for the Combinatorial Synthesis of Structurally Diverse Pyrimidines on Solid Support” Helvetica Chimica ACTA, Verlag Helvetica CH1MICA ACTA. Basel, CH, vol. 80, 1997, pp. 65-72. XP002915327 ISSN: 0018-019X.

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