Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2006-12-26
2006-12-26
Balasubramanian, Venkataraman (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S324000, C544S325000, C514S272000, C514S275000
Reexamination Certificate
active
07153964
ABSTRACT:
Pyrimidine derivatives of formula (I) wherein: Qh1and Q2are independently selected from aryl or carbon linked heteroaryl optionally substituted as defined within; and one of Q1and Q2or both Q1and Q2is substituted on a ring carbon by one group selected from sulphamoyl, N—(C1-4alkyl)sulphamoyl (optionally substituted by halo or hydroxy), N,N-di-(C1-4alkyl)sulphamoyl (optionally substituted by halo or hydroxy), C1-4alkylsulphonyl (optionally substituted by halo or hydroxy) or a substituent of the formula (Ia) or (Ia′): wherein Q1, Q2, G, R1, Y, Z, Q3, n and m are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) inhibitors are also described
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Breault Gloria Anne
Morris Jeffrey James
Pease Elizabeth Janet
AstraZeneca AB
Balasubramanian Venkataraman
Morgan & Lewis & Bockius, LLP
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