Pyrimidine compounds

Details Pyrimidine compounds Pyrimidine compounds

2005-02-22

2005-02-22

Balasubramanian, Venkataraman (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S231500, C514S272000, C514S275000, C544S317000, C544S320000, C544S321000, C544S326000, C544S328000, C544S330000, C544S331000, C544S111000

Reexamination Certificate

active

06858606

ABSTRACT:
This invention features pyrimidine compounds of formula (I):R1isin which one of Raand Rbis H or alkyl, and the other is aryl or heteroaryl optionally substituted with Rdand Rem; each of R2and R4is H; R3is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R5is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NRc; Y is covalent bond, CH2, C(O), C═N—Rc, C═N—ORc, C═N—SRc, O, S, S(O), S(O2), or NRc; Z is N or CH; one of U and V is N, and the other is CRc; and W is O, S, S(O), S(O2), NRc, or NC(O)Rc; in which Rcis H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; Rdis halogen, CN, alkyl alkyloxy, alkylcarbonyl, alkyloxycarbonyl, aryloxycarbonyl, heteroaryloxycarbonyl, hydroxyalkyl, alkylamino, or alkylaminocarbonyl; Reis halogen, CN, hydroxyl, alkyl, aryl, heteroaryl, alkoxyl, aryloxyl, or heteroaryloxyl; and m is 0, 1, 2, 3, or 4. The pyrimidine compounds can be used to treat an IL-12 overproduction-related disorder (e.g., rheumatoid arthritis, sepsis, Crohn's disease, multiple sclerosis, psoriasis, or insulin-dependent diabetes mellitus).

REFERENCES:
Trincheri , Current Opinion In Hematology 4: 59-66, 1997.*
Arvanitis, et al.Non-Peptide Corticotropin-Releasing Hormone Antagonists: Syntheses and Structure—Activity Relationships of 2-Anilinopyrimidines and -triazines. J. Med. Chem, vol. 42, 1999, pp. 805-818.
Mylari, et al.Sorbitol Dehydrogenase Inhibitors(SDIs):A New Potent, Enantiomeric SDI, 4-[2-1-R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic Acid Dimethylamide. J. Med Chem, vol. 44, 2001, pp. 2695-2700.

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