Pyrimidine biosynthesis inhibitors useful as immunosuppressive a

Details Pyrimidine biosynthesis inhibitors useful as immunosuppressive a Pyrimidine biosynthesis inhibitors useful as immunosuppressive a

1989-10-31

1992-04-07

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514903, 536 53, 536 55, A61K 3141, A61K 900, C07K 1702, G01N 33544

Patent

active

051028832

ABSTRACT:
The pyrimidine biosynthesis inhibitors dichloroallyl lawsone, N-(phosphonoacetyl)-L-aspartic acid (PALA), pyrazofurin, and derivatives thereof, are useful as immunomodulatory and anti-inflammatory agents. Pharmaceutical formulations containing these compounds are useful for the treatment of autoimmune diseases, chronic inflammatory diseases, and of organ transplantation rejections.

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Shih-Fong Chen et al., Cancer Research 46, 5014-5019, Oct. 1989.

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