Pyrimidine-4,6-dicarboxylic acid diamides for selectively...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S333000, C544S335000, C544S053000, C544S056000, C544S063000, C544S088000, C544S098000, C544S106000, C540S606000, C514S217060, C514S226800, C514S227500, C514S228800, C514S231500, C514S241000

Reexamination Certificate

active

10700273

ABSTRACT:
Pyrimidine-4,6-dicarboxylic acid diamides of the formula Iare suitable for selectively inhibiting collagenase (MMP 13). The pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerative joint diseases.

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Organikum, Organisch Chemisches Grundpratikum, 15. Aufl.., VEB Deutscher Verlag der Wissenschaften, 1976; Methodenregister, S. 822.

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