Pyrimidin-6-yl acethydroxamic acids

Details Pyrimidin-6-yl acethydroxamic acids Pyrimidin-6-yl acethydroxamic acids

1976-12-10

1977-12-06

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

42424854, C07D41312, A61K 31535

Patent

active

040618552

ABSTRACT:
Compounds of the formula ##STR1## IN WHICH R is aminocarbonylphenyl in which amino is --NH.sub.2, pyrrolidino, piperidino or morpholino, and Ar is phenyl substituted with chloro, fluoro, trifluoromethyl, methylenedioxy or one or more methoxy. The compounds are prepared by reacting 2-Ar-4-chloropyrimidin-6-yl ethylacetate with ##STR2## and then reacting that reaction product with hydroxylamine hydrochloride. The compounds possess vasodilatatory, anti-ulcerous, respiratory analeptic, hypotensive, diuretic, anti-depressive, analgesic, anti-inflammatory and neurotropic properties.

REFERENCES:
patent: 4013768 (1977-03-01), Fauran et al.

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