Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-01-17
2000-12-19
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
51425214, 51425301, 514269, 514308, 514333, 514335, 544298, 544316, 544319, 544295, 546148, 546256, 546261, A61K 31444, A61K 31506, C07D40112, C07D40312
Patent
active
061628093
DESCRIPTION:
BRIEF SUMMARY
FIELD OF APPLICATION OF THE INVENTION
The invention relates to compounds which are intended to be used in the pharmaceutical industry as active compounds for the production of medicaments.
DESCRIPTION OF THE INVENTION
The invention relates to compounds of the formula I (see attached formula sheet), in which carboxyl or cyano, N-1-4C-alkyl-N'-cyanoamidino radical, a 1-N-1-4C-alkylamino-2-nitroethylene radical, an N-2-propynyl-N'-cyanoamidino radical, an aminosulfonylamidino radical, the radical --N(R7)R8 or an R9- and R10-substituted cyclic system or bicyclic system which is selected from the group consisting of benzene, naphthalene, furan, thiophene, pyrrole, oxazole, isoxazole, thiazole, thiazoline, isothiazole, imidazole, imidazoline, pyrazole, triazole, tetrazole, thiadiazole, thiadiazole-i-oxide, oxadiazole, pyridine, pyridine-N-oxide, pyrimidine, triazine, pyridone, benzimidazole, imidazopyridine, benzothiazole, benzoxazole and quinoline, R13-substituted phenyl, or in which bonded, are an unsubstituted or substituted 5- or 6-membered ring hetero(bi)cyclic system, which is selected from the group consisting of piperidine, piperazine, morpholine, indoline, 1,2,3,4-tetrahydroquinoline and 1,2,3,4-tetrahydroisoquinoline, where identical or different substituents selected from the group consisting of 1-4C-alkyl, 1-4C-alkoxycarbonyl, hydroxy -1-4C-alkyl, phenyl, R11-, R12- and R13-substituted phenyl, phenyl-1-4C-alkyl, benzoyl, halogen-substituted benzoyl and carboxyl, 6-position by a 1-4C-alkyl radical and is substituted in the 4-position by a substituent selected from the group consisting of 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkyl-1-4C-alkyl, 1-4C-alkoxycarbonyl-1-4C-alkyl, carbamoyl, --C.sub.p H.sub.(2p-2) --R14 and --C.sub.q H.sub.2q --R14, different 1-4C-alkyl radicals, 3-position by a carboxyl group or by one or two identical or different 1-4C-alkyl radicals, and can be substituted in the benzo moiety by one or two identical or different substituents selected from the group consisting of 1-4C-alkyl, halogen and nitro, two identical or different substituents selected from the group consisting of 1-4C-alkyl and halogen, or two identical or different substituents selected from the group consisting of 1-4C-alkyl, carboxyl and phenyl, guanidino, carboxyl, 1-4C-alkoxycarbonyl, R15-substituted 1-4C-alkyl or --N(R16)R17, trifluoromethyl, halogen, 1-4C-alkylamino or nitro, selected from the group consisting of benzene, naphthalene, furan, thiophene, pyrrole, oxazole, isoxazole, thiazole, thiazoline, isothiazole, imidazole, imidazoline, pyrazole, triazole, tetrazole, thiadiazole, oxadiazole, pyridine, pyridine-N-oxide, pyrimidine, benzimidazole and quinoline, where bonded, are a piperidino or morpholino radical, system if Z is O, S, SO or SO.sub.2, v is the number 1 and u is the number 0.
1-4C-Alkyl represents straight-chain or branched alkyl radicals having 1 to 4 carbon atoms. tert-butyl, propyl, isopropyl, ethyl and methyl radicals.
Halogen within the meaning of the present invention is bromine, chlorine or fluorine.
1-4C-Alkoxy represents a radical which, beside the oxygen atom, contains one of the abovementioned 1-4C-alkyl radicals. Examples which may be mentioned are the methoxy and the ethoxy radicals.
1-4C-Alkoxycarbonyl represents a radical which, beside the carbonyl group, contains one of the abovementioned 1-4C-alkoxy radicals. Examples which may be mentioned are the methoxycarbonyl and the ethoxycarbonyl radicals.
Mono- or di-1-4C-alkylcarbamoyl radicals are carbamoyl radicals (--CO--NH.sub.2) which are substituted by one or two radicals which are identical to or different from the abovementioned 1-4C-alkyl radicals. Examples which may be mentioned are the methylcarbamoyl, the isopropylcarbamoyl and the dimethylcarbamoyl radicals.
Mono- or di-1-4C-alkylthiocarbamoyl radicals are thiocarbamoyl radicals (--CS--NH.sub.2) which are substituted by one or two radicals which are identical to or different from the abovementioned 1-4C-alkyl radicals. Examples which may be mentioned are the methylthi
REFERENCES:
Ota et al., Chemical Abstracts, vol. 108, abstract 186590u, 1988.
Grundler Gerhard
Kohl Bernhard
Senn-Bilfinger Jorg
ByK Gulden Lomberg Chemische Fabrik GmbH
Raymond Richard L.
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