Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Patent
1981-01-02
1983-03-15
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
2602391, 2602395, 424241, 424246, 424247, 424250, 424251, 424263, 424266, 544 24, 544 35, 544259, 544267, 544269, 544270, 544273, 544275, 544281, 546342, 546341, 546343, 546348, A61K 31625, C07D49932, C07D50138, C07D21355
Patent
active
043767672
ABSTRACT:
Novel pharmaceutically useful derivatives of selected known bio-affecting carboxylic acids are disclosed, said derivatives having the structural formula ##STR1## wherein R.sub.1 and R.sub.2, which can be the same or different, are each hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkylthio, phenyl, or substituted phenyl having one or more substituents each of which is selected from the group consisting of C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, chloro and dialkylamino wherein the alkyl portions, which can be the same or different, each have 1 to 5 carbon atoms, with the proviso that when R.sub.1 is alkoxy or alkylthio, then R.sub.2 cannot be alkoxy or alkylthio; X and X', which can be the same or different, are each hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.6 alkoxycarbonyl, halo, C.sub.1 -C.sub.5 alkoxy, dialkylcarbamyl wherein the alkyl portions, which can be the same or different, each have 1 to 5 carbon atoms, phenyl, or substituted phenyl the pyridyl ring is oriented such that it is attached to the ##STR2## portion of the molecule via a carbon-carbon bond; and R-COO- is the acyloxy residue of a monocarboxylic acid; a steroidal monocarboxylic acid; or a cephalosporin or penicillin antibiotic.
REFERENCES:
patent: 3883569 (1975-05-01), Phillips et al.
patent: 4001219 (1977-01-01), Baiocchi
patent: 4105668 (1978-08-01), Nakanishi
patent: 4219554 (1980-08-01), Saikawa et al.
Cheng Theresa Y.
Clarke Vera C.
Merck & Co. , Inc.
Monaco Mario A.
Riedl Edmunde D.
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