Pyridylalkyl phenyl ureas and their N-oxides

Details Pyridylalkyl phenyl ureas and their N-oxides Pyridylalkyl phenyl ureas and their N-oxides

1975-06-25

1977-01-04

Drezin, Norman A

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602955D, 424263, C07D21338

Patent

active

040012565

ABSTRACT:
A method of improving the endogenous production of prostaglandins by a mammal is disclosed, which comprises administering to the mammal an effective amount of certain 1-pyridylalkyl-3-phenylureas. Disclosed also are novel substituted 1-pyridylalkyl-3-phenylureas and therapeutic compositions thereof which are useful in carrying out the method of the invention.
Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as, for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.

REFERENCES:
patent: 3128280 (1964-04-01), Rorig
patent: 3700678 (1972-10-01), Mihailovski
Juby et al., J. Med. Chem. 10, pp. 491-495, (1967).
Sculley et al., J. Am. Chem. Soc., vol. 75, pp. 3400-3403, (1953).
Robison et al., J. Am. Chem. Soc. vol. 77, pp. 6554-6559, (1955).
Skinner et al., J. Org. Chem., vol. 25, pp. 2046-2047, (1960).
Novikov et al., Chemical Abstracts 70:77727v, (1969).

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