Pyridyl, thiazolyl and isothiazolyl alkyl bisamidines

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424270, 546291, 546296, 546300, 546305, 546306, 546330, 546332, 548186, 548189, 548202, 548203, 548204, 548205, 548213, 548214, A61K 3144, A61K 31425, C07D21354, C07D21360, C07D27730, C07D27732, C07D27505

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042859522

ABSTRACT:
Bisamidines carrying one unsaturated nitrogen heterocycle-containing substituent, representative of which is 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-8-[N'-methylgu anidino]octane, are histamine H.sub.2 -antagonists.

REFERENCES:
patent: 4034101 (1977-07-01), Durant et al.
patent: 4062967 (1977-12-01), Durant et al.

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