Pyridyl-substituted spiro-hydantoin compounds and use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S015000, C546S274400, C514S341000

Reexamination Certificate

active

11301454

ABSTRACT:
A class of substituted spiro-hydantoin compounds (II) having the formula:its pharmaceutically acceptable salts, enantiomers, solvates, or prodrugs thereof, wherein R16is a substituted pyridinyl group, as defined herein, is provided. Pharmaceutical compositions and methods of treating anti-inflammatory and/or immune diseases with the pyridyl-substituted spiro-hydantoin compounds are also objectives of this invention.

REFERENCES:
patent: 4931444 (1990-06-01), Van Wauwe et al.
patent: 5346913 (1994-09-01), Hsu et al.
patent: 5434176 (1995-07-01), Claussner et al.
patent: 5750553 (1998-05-01), Claussner et al.
patent: 6087509 (2000-07-01), Claussner et al.
patent: 6977267 (2005-12-01), Dhar et al.
patent: 2006/0074099 (2006-04-01), DelMonte et al.
patent: WO 98/39303 (1998-09-01), None
patent: WO 99/11258 (1999-03-01), None
patent: WO 99/20617 (1999-04-01), None
patent: WO 99/20618 (1999-04-01), None
patent: WO 99/49856 (1999-10-01), None
patent: WO 00/21920 (2000-04-01), None
patent: WO 00/39081 (2000-07-01), None
patent: WO 00/48989 (2000-08-01), None
patent: WO 00/59880 (2000-10-01), None
patent: WO 01/06984 (2001-02-01), None
patent: WO 01/07044 (2001-02-01), None
patent: WO 01/07048 (2001-02-01), None
patent: WO 01/07052 (2001-02-01), None
patent: WO 01/07440 (2001-02-01), None
patent: WO 01/30781 (2001-05-01), None
patent: WO 01/51508 (2001-07-01), None
patent: WO 01/58853 (2001-08-01), None
patent: WO 02/02522 (2002-01-01), None
patent: WO 02/02539 (2002-01-01), None
patent: WO 02/28832 (2002-04-01), None
patent: WO 02/42294 (2002-05-01), None
patent: WO 02/44181 (2002-06-01), None
patent: WO 02/059114 (2002-08-01), None
patent: WO 02/096426 (2002-12-01), None
patent: WO 03/029245 (2003-04-01), None
Arseniyadis, S. et al., “Kinetic Resolution of Amines: A Highly Enantioselective and Chemoselective Acetylating Agent with a Unique Solvent-Induced Reversal of Stereoselectivity”, Angew. Chem. Int. Ed., vol. 43, pp. 3314-3317 (2004).
Diamond, M.S. et al., “The dynamic regulation of integrin adhesiveness”, Current Biology, vol. 4, No. 6, pp. 506-517 (1994).
Joucla, M. et al., “Pyrrolidines from α-Amino-Acids Derivatives”, Tetrahedron Letters, vol. 26, No. 23, pp. 2775-2778 (1985).
Sanfilippo, P.J. et al., “Novel Thiazole Based Heterocycles as Inhibitors of LFA-1/ICAM-1 Mediated Cell Adhesion”, J. Med. Chem. vol. 38, No. 7, pp. 1057-1059 (1995).
Tsuge, O. et al., “Amino Acid Approach as a General Route to Nonstabilized Azomethine Ylides. Facile Generation of Parent Methaniminium Methylide and Its 1-Mono- and 1,1-Disubstituted Derivatives”, Chemistry Letters, pp. 973-976 (1986).
Tsuge, O. et al., “Simple Generation of Nonstabilized Azomethine Ylides through Decarboxylative Condensation of α-Amino Acids with Carbonyl Compounds via 5-Oxazolidinone Intermediates”, Bull. Chem. Soc. Jpn., vol. 60, pp. 4079-4089 (1987).

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