Pyridyl substituted cyclopentadienes for the treatment of inflam

Details Pyridyl substituted cyclopentadienes for the treatment of inflam Pyridyl substituted cyclopentadienes for the treatment of inflam

1995-04-05

1996-11-19

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514344, 514277, A61K 3144

Patent

active

055763391

ABSTRACT:
A class of 2,3-substituted cyclopenta-2,4-dienyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II: ##STR1## wherein each of R.sup.1 and R.sup.2 is independently selected from hydrido, lower alkyl, lower hydroxyalkyl, halo, lower haloalkyl, lower alkoxycarbonyl and carboxyl; and wherein each of R.sup.3 through R.sup.12 is independently selected from hydrido, halo, lower alkyl, lower alkylthio, cyano, hydroxyl, mercapto, lower haloalkyl, lower haloalkoxy, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower alkylsulfonyl, lower haloalkylsulfonyl and sulfamyl; provided R.sup.5 and R.sup.10 are not both hydrido or methoxy; or a pharmaceutically suitable salt or prodrug thereof.

REFERENCES:
patent: 4946993 (1990-08-01), Cortes
T. Hla and K. Neilson, Proc. Natl. Acad. Sci. USA, 89, 7384-7388 (1992).
J. L. Masferrer et al, Proc. Natl. Acad. Sci. USA, 89, 3917 (1992).
E. Meade et al, J. Biol. Chem., 268, 6610 (1993).
N. Futaki et al, Prostaglandins, 47, 1 (1994).
C. Allen et al, J. Org. Chem., 11, 268 (1946).
H. Zimmerman and J. Pincock, J. Amer. Chem. Soc., 95, 3246 (1973).
K. Hirao et al, J. Chem. Soc., Chem. Commun., 300 (1984).

Affiliated with

Also associated with

Rating

Pyridyl substituted cyclopentadienes for the treatment of inflam does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridyl substituted cyclopentadienes for the treatment of inflam, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridyl substituted cyclopentadienes for the treatment of inflam will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-541344