Pyridyl substituted B-lactam compounds

Details Pyridyl substituted B-lactam compounds Pyridyl substituted B-lactam compounds

1996-09-20

1998-06-02

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540355, 540356, 540357, 540364, 549510, 549511, C07D205085, C07D20508, C07D30514

Patent

active

057602190

ABSTRACT:
Pyridyl substituted .beta.-lactam compounds used in preparing taxane derivatives having a 3' pyridyl substituted C13 side chain.

REFERENCES:
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5015744 (1991-05-01), Holton
patent: 5059699 (1991-10-01), Kingston et al.
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5254703 (1993-10-01), Holton
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5274124 (1993-12-01), Holton
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5336785 (1994-08-01), Holton
patent: 5338872 (1994-08-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5384399 (1995-01-01), Holton
patent: 5399726 (1995-03-01), Holton et al.
patent: 5405972 (1995-04-01), Holton et al.
patent: 5430160 (1995-07-01), Holton
patent: 5466834 (1995-11-01), Holton
patent: 5489601 (1996-02-01), Holton et al.
patent: 5532363 (1996-07-01), Holton
patent: 5539103 (1996-07-01), Holton
Bartholomew et al., "A Novel Rearrangement Reaction Conversion of 3-(chloromethyl)azetidin-2-ones to Azetidine-3-carboxylic Acid Esters", Tetrahedron Letters, vol. 32, No. 36 (1991) pp. 4795-4798.
Borman "New Family of Taxol, Taxotere Analogs Developed" Science & Technology, Chemical & Engineering News, Apr. 12, 1993.
Chen et al., "Taxol Structure-Activity Relationships: Synthesis and Biological Evaluation of 2-Deoxytaxol" Tetrahedron Letters, vol. 34, No. 20 (1993) pp. 3205-3206.
Denis et al. "A Highly Efficient, Practical Approach to Natural Taxol", Journal of American Chemical Soc., vol. 110, (1988) pp. 5917-5919.
Deutsch et al. "Synthesis of Congeners and Prodrugs. 3. Water-Soluble Prodrugs of Taxol With Potent Antitumour Activity", Journal of Medicinal Chem., vol. 32, No. 4 (Apr. 1989) pp. 788-792.
Farina et al. "The Chemistry of Taxanes: Unexpected Rearrangement of Baccatin III During Chemoselective Debenzoylation With Bu.sub.3 SnOMe/LiCl", Tetrahedron Letters, vol. 33, No. 28 (1992) pp. 3979-3982.
Georg et al. "Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-Chlorobenzoyl)-(2'R, 3'S)-3'-phenylisoserinate) and Baccatin III 13-(N-Benzoyl-(2'R,3'S)-3'-(p-chlorophenyl) isoserinate)" Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 4 (1992) pp. 295-298.
Holton "Synthesis of the Taxane Ring System" Journal of American Chemical Soc., vol. 106 (1984) pp. 5731-5732.
Holton et al. "A Synthesis of Taxusin", Journal of American Chemical Soc., vol. 110 (1988) pp. 6558-6560.
Kaiser et al. "Synthesis of Esters of Acid-Unstable Alcohols by Means of n-butyllithium" Journal of Organic Chemistry, vol. 35 (1970) p. 1198.
Kingston et al. "Progress in the Chemistry of Organic Natural Products" Springer-Verlag, New York (1993) pp. 1-206.
Klein "Synthesis of 9-Dihydrotaxol: A Novel Bioactive Taxane" Tetrahedron Letters, vol. 34, No. 13 (1993) pp. 2047-2050.
Magri et al. "Modified Taxols, 4. Synthesis and Biological Activity of Taxols Modified in the Side Chain" Journal of Natural Products, vol. 51, No. 2 (1988) pp. 298-306.
Miller et al. "Antileukemic Alkaloids From Taxus Wallichiana Zucc." Jour. of Organic Chem., vol. 46 (1981) pp. 1469-1474.
Mukerjee et al. ".beta.-Lactams: Retrospect and Prospect" Tetrahedron Letters, vol. 34, No. 52 (1978) pp. 1731-1767.
Ojima et al. "New and Efficient Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Method" Tetrahedron Letters, vol. 48, No. 34 (1992) pp. 6985-7012.
Samaranayake et al. "Modified Taxols. 5.1 Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity3." Journal of Organic Chemistry, vol. 56, No. 17 (1991) pp. 5114-5119.
Schultz et al "Synthesis of New N-radicals of Tetrazan-1-yl" Chemical Abstracts, vol. 108, No. 37298C (1988) p. 581.
Senilh et al. "Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C.R. Acad. Sc. Paris, Serie II, vol. 229, No. 15 (Nov. 21, 1984) pp. 1039-1043.
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent From Taxus Brevifolia" Jurnal of American Chemical Soc., vol. 93, No. 9 (May 5, 1971) pp. 2325-2327.
Witherup et al., "High Performance Liquid Chromatographic Separation of Taxol and Related Compounds From Taxus Brevifolia" Journal of Liquid Chromatography, vol. 12, No. 11 (1989) pp. 2117-2132.
M. Hepperle et al. "104. The Remarkable Potency of Hetero-aromatic Taxol Analogues" 207th ACS National Meeting, American Chemical Society, San Diego, CA (Mar. 13-17, 1994) (University of Kansas).

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