Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-11-30
2010-10-05
Davis, Zinna N (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S152000, C546S255000, C546S272700, C544S333000, C514S314000, C514S332000, C514S341000
Reexamination Certificate
active
07807682
ABSTRACT:
Compounds according to formula Iwherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, carboxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, amino, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy or phosphono; X represents a straight or branched, saturated or unsaturated C1-12hydrocarbon diradical, optionaly substituted with halogen, hydroxy, cyano, nitro, carboxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, amino, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy or phosphono; Y represents a bond, 0, C(O), S, S(O), S(0)2, C(O)O, NH, C(O)NH, OC(O) or NHC(O); Z represents an aromatic or non-aromatic heterocyclic radical with 5-12 ring atoms, optionally substituted with halogen, hydroxy, cyano, nitro, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, aminoalkyl or straight or branched, saturated or unsaturated C1-4hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl or aminoalkyl; provided that R1 is not attached to the nitrogen-atom in the pyridyl ring; and pharmaceutically acceptable salts, solvates, hydrates, N-oxides and prodrugs thereof are disclosed. The compounds are useful in therapy.
REFERENCES:
patent: 5696140 (1997-12-01), Bramm et al.
patent: 7129043 (2006-10-01), Boustany et al.
patent: WO-94/06770 (1994-03-01), None
patent: WO 94/06770 (1994-03-01), None
patent: WO-98/54141 (1998-12-01), None
patent: WO 98/54141 (1998-12-01), None
patent: WO-98/54142 (1998-12-01), None
patent: WO 98/54142 (1998-12-01), None
patent: WO-98/54143 (1998-12-01), None
patent: WO 98/54143 (1998-12-01), None
patent: WO-98/54144 (1998-12-01), None
patent: WO 98/54144 (1998-12-01), None
patent: WO-98/54145 (1998-12-01), None
patent: WO 98/54145 (1998-12-01), None
patent: WO-00/61559 (2000-10-01), None
patent: WO 00/61559 (2000-10-01), None
patent: WO-00/61561 (2000-10-01), None
patent: WO 00/61561 (2000-10-01), None
patent: WO-01/09096 (2001-02-01), None
patent: WO-02/62762 (2002-08-01), None
West, Anthony R., Solid State Chemistry and its Applications, Wiley, New York, 1988, pp. 358 & 365.
Boschi et al, Bioorganic & Medicinal Chemistry, 2000, vol. 8, pp. 1727-1732.
Japanese Office Action issued for corresponding Japanese Application No. 2002-591486, issued on Jan. 27, 2009 (4 pages).
Moriguchi, et al. “Adaptive Least-Squares Method Applied to Structure-Activity Correlation of Hypotensive N-Alkyl-N″-cyano-N′pyridylguanidines.” Journal of Medicinal Chemistry, vol. 23, No. 1, 20-26. 1980.
Ekelund, Sara et al.: Biochemical Pharmacology, vol. 60, 2000, pp. 839-849, XP002902626.
Schou, C et al.: Bioorganic & Medicinal Chemistry Letters, Oxford, vol. 7, No. 24, 1997, pp. 3095-3100, XP002079955.
Chen, Jianyong et al.: Journal of China Pharmaceutical University, vol. 24, No. 4, 1993, pp. 202-204, SP002902627.
Sara Ekelund et al.: Biochemical Pharmacology, vol. 60, 2000, pp. 839-849, XP002902626.
Schou C et al. : Bioorganic & Medicinal Chemistry Letters, Oxford, vol. 7, No. 24, 1997, pp. 3095-3100, XP002079955.
Chen Jianyong et al. : Journal of China Pharmaceutical University, vol. 24, No. 4, 1993, pp. 202-204, SP002902627.
Hjarnaa, et al.: “CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity in Vitro and in Vivo”, Cancer Research 59, Nov. 15, 1999, pp. 5751-5757.
Davis Zinna N
Leo Pharma A/S
Wilmer Cutler Pickering Hale and Dorr LLP
LandOfFree
Pyridyl cyanoguanidine compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyridyl cyanoguanidine compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridyl cyanoguanidine compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4166295