Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-01-19
1994-02-15
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514336, 514339, 546273, 546284, 546331, 546332, 546335, C07D21356
Patent
active
052867366
ABSTRACT:
New pyridyl derivatives of the formula ##STR1## wherein R.sub.1 to R.sub.6, A, X and n are as defined herein, the enantiomers thereof, the cis- and trans-isomers thereof if R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof. The new pyridyl derivatives have antithrombotic activity and thromboxane-mediated activities. The new compounds are also simultaneously thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 -production.
REFERENCES:
Chemical Abstracts, vol. 114, No. 21, Abstract 207035h, pp. 808-809, May 27, 1991.
Lefer, DN&P, 2(5), Aug. 1989, pp. 265-269.
Halushka, Kardiol, 78 (Suppl. 3) 1989, pp. 42-47.
O'Byrne et al, Eur. Respir. J., No. 2, 1989, pp. 782-786.
Smith, Eicosanoids, No. 2, 1989, pp. 199-212.
Eisert Wolfgang
Mueller Thomas
Soyka Rainer
Weisenberger Johannes
Davis Zinna N.
Dr. Karl Thomae GmbH
Frankhouser David E.
Rotman Alan L.
Stempel Alan R.
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