Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-02-28
1993-06-29
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546330, 546284, 514357, C07D21378, A61K 3144
Patent
active
052235084
ABSTRACT:
Novel carboximidamide derivatives represented by the following formula (A) and acid adduct salts thereof are disclosed: ##STR1## wherein all the substituents have the same meanings as defined above. N-cyano-pyridinecarboxyimidate compounds represented by the following formula (II) which are the intermediates for preparing of N-cyano-N'-substituted-pyridinecarboximidamide derivatives wherein the substituent B in the above described formula (A) is pyridine are also disclosed: ##STR2## wherein all the substituents have the same meanings as defined above. The process for preparing the compounds, the pharmaceutical agents comprising the compound having vasodilating effect, and the therapeutic method of dosing the compound on patients for therapy are also disclosed.
REFERENCES:
Kinney et al. Journal of Medicinal Chemistry, vol. 33, pp. 327-336, 1990.
Izawa et al., Chemical Abstracts, vol. 114, No. 23, Abstract 228,747g, p. 822, Jun. 10, 1991.
Izawa Toshio
Kashiwabara Tomoko
Nakajima Shohachi
Ogawa Nobuyuki
Davis Zinna N.
Ivy C. Warren
Kirin Beer Kabushiki Kaisha
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