Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-05-03
1985-09-17
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514354, 546322, 546326, C07D21379, C07D21380, A61K 31455
Patent
active
045421439
ABSTRACT:
Ascochlorin derivatives of the formula: ##STR1## wherein R is a hydroxyl group, a lower alkoxy group, a pyridyl group, an amino group, a dialkylamino group, a phenoxyalkyl group which may have a substituent in the nucleus, or a phenyl group which may have a substituent in the nucleus; and n is an integer of 0 to 5, a process for preparing the same and a pharmaceutical composition containing the same are disclosed.
The derivatives are useful to treat diabetes, improve lipid metabolism and control tumors.
REFERENCES:
patent: 3546073 (1970-12-01), Evans et al.
patent: 3995061 (1976-11-01), Hosokawa et al.
Chem. Abstracts, vol. 94:96316x.
Chem. Abstracts, vol. 86:34279p.
Sherif, E. A. et al., "Synthesis of Chalcones, Flavanones Isolated from Popowia Cauliflora and their Analogs", Agric. Biol. Chem., vol. 45(2), 531-533, (1981).
Ando Kunio
Hosokawa Tomoyoshi
Matsuura Ikutoshi
Takahashi Hidenori
Tamura Gakuzo
Bjorkman Dale A.
Chugai Seiyaku Kabushiki Kaisha
Jiles Henry R.
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