Pyridyl and quinoline derivatives

Details Pyridyl and quinoline derivatives Pyridyl and quinoline derivatives

1986-02-28

1989-05-02

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546170, 546172, 546176, 546177, 546286, 546288, 546289, 546290, 546296, 546297, 546298, 546299, 546300, 546301, 546302, 546 22, C07D21330, C07D21332, C07D21514

Patent

active

048269875

ABSTRACT:
The present invention relates to compounds of formula I ##STR1## in which formula I X stands for O, S, ##STR2## R.sub.1 and R.sub.2 which can be the same or different stand for hydrogen, straight or branched, saturated or unsaturated, unsubstituted or substituted C.sub.1 -C.sub.8 -alkyl, or for ar-C.sub.1 -C.sub.4 -alkyl, aryl and ar being unsubstituted or substituted phenyl; R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are the same or different and stand for hydrogen, halogen, pseudo halogen, cyano, nitro, amino, carboxy, hydroxy, alkyl, alkoxy; or R.sub.5 and R.sub.6 form an aromatic ring which is fused to the pyridyl ring, and which aromatic ring may substituted; provided that R.sub.1 and R.sub.2 cannot be hydrogen at the same time, and provided that when R.sub.5 and R.sub.6 both are chlorine and R.sub.1 is hydrogen, then R.sub.2 cannot be n-propyl; and salts and bioreversible derivatives thereof.
The compounds of formula I are useful in the human and veterinary therapy, as they exert specific 5-lipoxygenase inhibition.

REFERENCES:
patent: 4554355 (1985-11-01), Musser
patent: 4563463 (1986-01-01), Musser et al.
patent: 4567184 (1986-01-01), Musser et al.

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