Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3

Details Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3

2006-10-05

2011-11-08

Chung, Susannah (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S250000

Reexamination Certificate

active

08053454

ABSTRACT:
Compounds of formula (I), useful for inhibiting PIM-I and/or PIM-3: and pharmaceutically acceptable salts thereof, wherein Y, Z, R1, R3, Q, X and R4are as defined above. Pharmaceutical compositions and methods of treating diseases and conditions, such as cancer, are also disclosed.

REFERENCES:
patent: 3636094 (1972-01-01), Yonan
patent: 2004/0142981 (2004-07-01), Thorarensen et al.
patent: 0 628 555 (1994-12-01), None
patent: 1 276 359 (1972-06-01), None
patent: 62/012753 (1987-01-01), None
patent: 62/255458 (1987-11-01), None
patent: 04/342577 (1992-11-01), None
patent: 02/50031 (2002-06-01), None
patent: 2004/022525 (2004-03-01), None
patent: 2004/022529 (2004-03-01), None
patent: WO 2004/022525 (2004-03-01), None
patent: 2004/034972 (2004-04-01), None
patent: 2004/046090 (2004-06-01), None
patent: 2004/046140 (2004-06-01), None
patent: 2004/058769 (2004-07-01), None
Patini, et al., Chem. Rev., 1996, 96, 3147-3176, esp. pp. 3146 and 3147.
Valgeirsson, Jon et al., “Bioisosteric Modifications of 2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5”, Journal of Medicinal Chemistry, 2004, 47(27), 6948-6957.
Valgeirsson, Jon et al., “2-Arylureidobenzoic Acids: Selective Noncompetitive Antagonists for the Homomeric Kainate Receptor Subtype GluR5”, Journal of Medicinal Chemistry, 2003, 46(26), 5834-5843.
Biagi, Giuliana et al., “Some structural changes on triazolyl-benotriazoles and triazolyl-benzimidazolones as potential potassium channel activators. III”, Farmaco, 2001, 56(11), 841-849.
Avotin'sh, F. M. et al., “2-[(3-Ethyl-2,2-dimethylcyclobutyl) methyl]-4(3H)-quinazolinones”, Chemistry of Heterocyclic Compounds, 1999, 35(6), 722-728.
Osborne, A. G. et al., “1H and 13C NMR spectral studies of some 4H-3,1-benzoxazin-4-ones and their 2-acylaminobenzoic acid precursors”, Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy, 2000, 56A(6), 1079-1100.
Johnson, Judith L. et al., “Synthesis of NSC-341,964: an unexpected study on the stability of 2-aryl-4H-3,1-benzoxazin-4-ones”, Journal of Heterocyclic Chemistry, 1986, 23(1), 249-251.
Ryznerski, Zygmunt et al., “Synthesis and antiinflammatory properties of N-(2-carboxyphenyl)phenoxyacetamides”, Chemical Abstract Service, XP002425195, Database accession No. 1980:567828.
Sunder, Shyam et al., “Synthesis of benzofuro[3,2-b]quinolin-6(11H)one and derivatives”, Journal of Heterocyclic Chemistry, 1978, 15(8), 1379-1382.
Heyman, Duane A., “Preparation of isatoates from isatoic anhydride”, Journal of Heterocyclic Chemistry, 1978, 15(7), 1131-1136.
Archer, John G. et al., “1,2,3-Benzotrianzin-4-ones and related systems. II. Thermolytic decomposition of substituted 1,2,3-benzotriazin-4-ones and isatoic anhydrides”, Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, 1972-1999, vol. 11, 1169-1173.
Felix, Arthur M. et al., “Synthesis and diuretic properties of some N-alkylaminocarbonyl- and N-pyrrolylcarbonylanthranilic acid derivatives”, Journal of Medicinal Chemistry, 1969, 12(3), 384-387.
Itami, Yasuo et al., “Preparation of herbicidal fluorinated alkanecarboxamides.”, Chemical Abstracts Service, Columbus, Ohio, XP002425196, Database accession No. 1988:200216.

Affiliated with

Also associated with

Rating

Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4282339