Pyridopyrimidine nucleotide compounds

Details Pyridopyrimidine nucleotide compounds Pyridopyrimidine nucleotide compounds

1989-05-11

1990-10-23

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 27, 536 29, A61K 3170

Patent

active

049653504

ABSTRACT:
Pyridopyrimidine nucleotide derivatives expressed by formula (I), which are fluorescent and capable of forming base pairing with guanine or adenine, and oligo- or polynucleotide which have at least one of these derivatives in their molecules or at their molecular terminals: ##STR1## wherein X.sub.1 and X.sub.1 respectively represent ##STR2## (in which n indicates an integer of 0, 1, 2, or 3; however, in no case X.sub.1 and Y.sub.1 both indicate n=O); Z.sub.1 indicates a hydrogen atom or ##STR3## (in which n indicates an integer of 1, 2, or 3); W.sub.1 indicates a hydrogen atom or a hydroxyl group. As for R.sub.1 and R.sub.2, in case where R.sub.1 is an amino group or halogen, R.sub.2 indicates a single bond between the carbon atom at the 7-position and the nitrogen atom at the 8-position, and in case where R.sub.2 is a hydrogen atom or an lower alkyl group, R.sub.1 indicates a carbonyl bond ##STR4## formed with the carbon atom at the 7-position.

REFERENCES:
patent: 4711955 (1987-12-01), Ward et al.
Bergstrom et al., J. Org. Chem. 47, 2174-2178 (1982).
Schattenkerk et al., Nucleic Acid Research, 11 (No. 21) pp. 7545-7554 (1983).

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