Pyridopyrimidine derivatives, their production and use

Details Pyridopyrimidine derivatives, their production and use Pyridopyrimidine derivatives, their production and use

1995-06-07

1997-08-05

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544279, 544245, 544311, C07D47104, C07D239545, C07D47122, A61K 31505

Patent

active

056543093

ABSTRACT:
Pyridopyrimidine derivatives of the formula (A), wherein n denotes an integer of 0 to 3, Q stands for --(CH.sub.2).sub.m --, --O--, --S(O).sub.P -- or --N--, and R.sup.1 to R.sup.5 stand for substituents, where R.sup.3 is an optionally substituted phenyl, naphthyl, pyridyl, quinolyl, quinolonyl, or thienyl group; or its salt are described. Preparation and use of the derivatives for an antagonistic agent for an endothelin receptor are shown. An endothelin receptor antagonist including the derivative is effective as a therapeutic composition of acute renal insufficiency, myocardial infarction, hypertension, cerebral infarction, angina pectoris, arteriosclerosis, hepatopathy, pulmonary hypertension, bronchial asthma, organohypofunction occurring during operation of transplantation of organs. ##STR1##

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