Pyridopyrimidine analogs and related compounds and methods for t

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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544279, C07D47104, A61K 314745

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active

06150372&

ABSTRACT:
Compounds having utility as anti-inflammatory agents in general and, more specifically, for the prevention and/or treatment of immunoinflammatory and autoimmune diseases are disclosed. The compounds are quinazoline-containing compounds. Methods are also disclosed for preventing and/or treating inflammatory conditions by administering to an animal in need thereof an effective amount of a compound of this invention, preferably in the form of a pharmaceutical composition.

REFERENCES:
patent: 4322420 (1982-03-01), Kobayashi et al.
patent: 5939421 (1999-08-01), Palanki et al.
El-Sherief et al., "Quinazoline Derivatives from 2-Phenyl-4-quinazolinylhydrazine," Bull. Chem. Soc. Jpn. 57(4): 1138-1142, 1984.
El-Bahaie et al., "Reactions with 4-carboxymethylthio-2-phenyl-5-acetylpyrimidine," Chem. Abs. 116: Abstract No. #151703W, p. 874, 1992.
El-Bahaie et al., "Reactions with 4-Carboxymethylthio-2-phenyl-5-acetylpyrimidine.", J. Pol. Chem., 1991, vol. 65 (5-6), pp. 1059-1064.

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