Pyridopyridazine derivatives

Details Pyridopyridazine derivatives Pyridopyridazine derivatives

1972-12-15

1976-04-06

Weinberger, Lorraine A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602475DP, 260250AC, 424250, 424248, C07D29500

Patent

active

039489086

ABSTRACT:
A pyrido [3,4-d] pyridazine derivative is provided herein of the formula: ##SPC1##
Wherein R.sub.1 is hydrogen or an alkyl group of 1 to 4 carbon atoms; R.sub.2 is an alkyl group of 1 to 4 carbon atoms, an aralkyl group of 7 to 8 carbon atoms, or a substituted or unsubstituted phenyl, naphthyl, furyl or pyridyl, the substituent being a lower alkoxy group of 1 to 3 carbon atoms, a lower alkyl group of 1 to 3 carbon atoms, halogen or nitro; R.sub.3 is hydrogen or a lower alkoxy group of 1 to 4 carbon atoms; and R.sub.4 is a substituted or unsubstituted morpholino, piperidino or pyrrolidino, the substituent being methyl or ethyl and a pharmaceutically acceptable salt thereof. The compounds of the present invention have effective and strong diuretic action and exhibit extremely low toxicity characteristics.

REFERENCES:
patent: 3186991 (1965-06-01), Ohnacker
patent: 3248395 (1966-04-01), Ohnacker
patent: 3296251 (1967-01-01), Bell et al.
patent: 3454557 (1969-07-01), Patchett et al.
patent: 3622569 (1971-11-01), Lemieux
patent: 3711476 (1973-01-01), Diebold et al.
patent: 3749717 (1973-07-01), Haugwitz et al.
patent: 3764598 (1973-10-01), Yurgi et al.
Matsuo et al., J. of the Pharm. Soc. of Japan, Vol. 92, No. 6, pp. 703-707 (June 1972).

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