Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-04-05
2011-04-05
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S122000
Reexamination Certificate
active
07919502
ABSTRACT:
The present invention provides a compound of Formula Ior a pharmaceutically acceptable salt form thereof, wherein A, L1, R1, R2, R3, R4, R5, R6, and X are as defined herein. The compounds of Formula I have ALK and/or c-Met inhibitory activity, and may be used to treat ALK- or c-Met-mediated disorders or conditions.
REFERENCES:
patent: 4296114 (1981-10-01), Appleton et al.
patent: 5283244 (1994-02-01), Sakamoto et al.
patent: 5393771 (1995-02-01), Atwal
patent: 5424311 (1995-06-01), Billhardt-Troughton et al.
patent: 5521170 (1996-05-01), Setoi et al.
patent: 6150356 (2000-11-01), Lloyd et al.
patent: 6166031 (2000-12-01), Eggler et al.
patent: 6492389 (2002-12-01), Huang et al.
patent: 6809097 (2004-10-01), Thomas et al.
patent: 6809113 (2004-10-01), Laborde et al.
patent: 2003/0232818 (2003-12-01), Anderson et al.
patent: 2004/0019058 (2004-01-01), Bridger et al.
patent: 2004/0121996 (2004-06-01), Barvian et al.
patent: 2004/0138199 (2004-07-01), Gogliotti et al.
patent: 2 475 320 (2003-08-01), None
patent: 11292877 (1999-10-01), None
patent: WO00/00478 (2000-01-01), None
patent: WO2004/076412 (2004-09-01), None
patent: WO2005/009967 (2005-02-01), None
patent: WO2005/019236 (2005-03-01), None
patent: WO2005/021547 (2005-03-01), None
patent: WO2005/028451 (2005-03-01), None
patent: WO2007/024949 (2007-03-01), None
Appendino et al. Chemoselective Esterification of Phenolic Acids and Alcohols. 2002, Organic Letters, 4, 3839-3841.
Sako, M., “Product class 20: pyridopyrazines,” Science of Synthesis, 2004, 16, 1269-1290.
Vinot, N. et al., “Study of the reaction of organomagnesium compounds with pyrido[2,3-b]pyrazines,” Bulletin de la Societe Chimique de France, 1976, 1-2, Pt. 2, 251-254.
Vinot, N. et al., “Reduction of pyrido[2,3-b]pyrazines by lithium aluminum hydride,” Bulletin de la Societe Chimique de France, 1973, 11, Pt. 2, 3100-3102.
Settimo, A. et al., “Synthesis of some 11H-indolo[3,2-c][1,8]naphythyridines,” Il Farmaco—Ed. Sc., 1978, 33, 770-780.
PCT Written Opinion for PCT/US2007/010656, Nov. 4, 2008.
PCT International Search Report for PCT/US2007/010656, Dec. 15, 2007.
Chemical Abstracts Registry Database XP002456370, Apr. 27, 2007.
Chemical Abstracts Registry Database XP002456371, Apr. 23, 2007.
Chemical Abstracts Registry Database XP002456372, Apr. 23, 2007.
Chemical Abstracts Registry Database XP002456373, Apr. 22, 2007.
Chemical Abstracts Registry Database XP002456374, Apr. 22, 2007.
Chemical Abstracts Registry Database XP002456375, Apr. 22, 2007.
Chemical Abstracts Registry Database XP002456376, Apr. 22, 2007.
Chemical Abstracts Registry Database XP002456377, Apr. 22, 2007.
Chemical Abstracts Registry Database XP002456378, Apr. 22, 2007.
Chemical Abstracts Registry Database XP002456379, Apr. 20, 2007.
Chemical Abstracts Registry Database XP002456380, Apr. 20, 2007.
Dorsey Bruce D.
Pippin Douglas A.
Theroff Jay P.
Zificsak Craig A.
Cephalon Inc.
McDowell Brian
Wilson James O
LandOfFree
Pyridopyrazines and derivatives thereof as ALK and c-MET... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyridopyrazines and derivatives thereof as ALK and c-MET..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridopyrazines and derivatives thereof as ALK and c-MET... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2668279