Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1990-08-09
1991-09-24
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142355, 544131, 546277, 546287, 546288, C07D21364, A61K 3144
Patent
active
050514318
ABSTRACT:
Pyridones of formula (I) for treating congestive heart failure: ##STR1## wherein: R.sup.1 and R.sup.2 are a variety of phenyl substituents, L is a divalent alkylene or amide containing alkylene linking group. Pharmaceutical composition, methods for their use in treating cardiovascular conditions, processes used in synthesis and intermediates used in such processes.
REFERENCES:
patent: 4397854 (1983-08-01), Sicar
patent: 4413127 (1983-11-01), Singh
patent: 4608383 (1986-08-01), Wiedemann
Slater, R. A. et al., J. Med. Chem. 31, pp. 345-351 (1988).
Curran, W. V. et al., J. Med. Chem., vol. 17, No. 3, pp. 273-281 (1974).
Kenakin Terrence P.
Shaffer Joel E.
Wheeler Thomas N.
Glaxo Inc.
Lee Mary C.
Levy David J.
Mittenberger Lenora A.
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