Pyridone esters as inotropic agents

Details Pyridone esters as inotropic agents Pyridone esters as inotropic agents

1985-07-12

1987-04-14

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546261, C07D40106, A61K 3144

Patent

active

046579192

ABSTRACT:
Described are compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, --CH.sub.2 NH.sub.2, --CH.sub.2 OH or --COOR"; R' is hydrogen, lower cycloalkyl or lower alkyl; R' is lower alkenyl, lower alkynyl, lower cycloalkyl, --(W).sub.n Y wherein W is straight or branched chain lower alkyl or lower alkenyl, n is 0 to 5, and Y is Ar, lower cycloalkyl, lower alkenyl, lower alkynyl, --COOZ wherein Z is lower alkyl, ##STR2## or NAB wherein A and B are, independently, lower alkyl, benzyl or substituted benzyl, and Ar is 2, 3 or 4-pyridyl, pyridazinyl, pyrimidinyl, quinolyl, isoquinolyl, phthalazinyl, quinazolinyl, thiazolyl, phenyl, benzyl, furyl, tetrahydrofuryl or thienyl, unsubstituted or substituted with lower alkyl, lower alkoxy, halo, amino, or --CF.sub.3 ; R"' is --COOR", ##STR3## and X is oxygen or nitrogen; or a pharmaceutically acceptable salt thereof, and their use in the treatment of impaired ventricular myocardial contractility.
The compounds exhibit cardiotonic activity.

REFERENCES:
patent: 3853897 (1974-12-01), Witzel et al.
patent: 4412077 (1983-10-01), Lesher et al.
patent: 4415580 (1983-11-01), Lesher et al.
patent: 4447619 (1984-05-01), Grisar et al.
patent: 4469699 (1984-09-01), Lesher et al.
patent: 4517192 (1985-05-01), Lesher
patent: 4530842 (1985-07-01), Bormann
Opgenorth et al, CA 90:54840a.
Sunthankar et al, CA vol. 80, 133202r.
Hirota et al, CA 94:103325e.
Duffield et al. CA vol. 65, 3152f.
Harris et al, CA vol. 64, 18224d.
Badische, CA vol. 64, 9694h.
Neuhoff et al, CA 7540g, vol. 61.
Arnold et al. CA 7725i, 1962.
Hirota et al. Chem. Abs.. vol. 95, 1981, 95:132434r.
Sano et al., Chem. Abst., vol. 88, 1978, 88:169907d.
Anghelide et al., Chem. Abst., vol. 81, 1974, 77429b.
Baker et al, J. Chem. Soc. Perkin Trans. I. (3) 1979, pp. 677-685.
DeJohn et al, J. Het. Chem. 20, 1295, 1983, Hawald et al.
Indian, J. Chem. Sect. B, 19B (2), 151-152, 1980.
Sunthankav et al, Ind. J. Chem. 1973, 11(12) pp. 1315-1316.
Scott et al, CA 90:174685a.
Hirota et al, CA 102:184956v.

Affiliated with

Also associated with

Rating

Pyridone esters as inotropic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridone esters as inotropic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridone esters as inotropic agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1785983