Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-08-03
1985-11-26
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514340, 514341, 514348, 514349, 514350, 546278, 546275, 546283, 546284, 546288, 546296, 546297, 546298, 546299, C07D21379, C07D41304, C07D40106, A61K 31455
Patent
active
045555176
ABSTRACT:
Described are compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, --CH.sub.2 NH.sub.2, CH.sub.2 OH or COOR"; R' is hydrogen, lower cycloalkyl or lower alkyl; R" is lower alkyl or --CH.sub.2 Ar wherein Ar is phenyl, substituted phenyl, furan or thiophene; R'" is COOR", ##STR2## and x is oxygen or nitrogen; or a pharmaceutically acceptable salt thereof and their use in the treatment of impaired ventricular myocardial contractility.
The compounds exhibit cardiotonic activity.
REFERENCES:
patent: 3853897 (1974-12-01), Witzell et al.
patent: 4447619 (1984-05-01), Grisar et al.
Derwent Abstract of European Pat. No. 124,090 (4/29/83).
Baker, S. R. et al., "Polyketo-enols and Chelates" J. Chem. Soc., Perkin Trans. I (3), pp. 677-685 (1979).
DeJohn, D. et al., "Functionalization of Substituted 2(1H)- and 4(1H)-Pyridones" J. Heterocyclic Chem., 20, pp. 1295-1302 (1983).
Hawaldar, V. S. et al., "Synthesis of Pyridones" Indian J. Chem., Sect B, 19B(2), pp. 151-152 (1980).
Sunthankar, S. V., "Reactions of Conjugated Ethers" Indian J. Chem. 11(12), pp. 1315-1316 (1973).
Barcelon-Yang Cynthia
Stout David M.
Yamamoto Diane M.
American Hospital Supply Corporation
Bjorkman Dale A.
Fato Gildo E.
Jiles Henry R.
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