Pyridoindoles

Details Pyridoindoles Pyridoindoles

1974-11-08

1976-11-09

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260240K, 26029355, C07D47104

Patent

active

039911993

ABSTRACT:
Certain trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido-[4,3-b] indoles useful as analgesics and sedatives. Some are also useful as major (antipsychotics) and/or minor (anxiolytics) tranquilizers, muscle relaxants, or hypotensives. The compounds of this invention are made by borane/THF reduction of .DELTA..sup.4a,9b -tetrahydro precursors, followed where necessary by dealkylation, alkylation and/or acylation/reduction.

REFERENCES:
patent: 3657254 (1972-04-01), Barkov et al.
patent: 3812135 (1974-05-01), Okamoto et al.
Heath-Brown, Chemistry and Industry, 1969, pp. 1595-1596.
Fieser et al., Advanced Organic Chemistry, pp. 92-104, N.Y., Reinhold, 1961.

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