Pyridoazepine derivatives

Details Pyridoazepine derivatives Pyridoazepine derivatives

2011-03-01

2011-03-01

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S215000, C540S521000, C540S578000, C540S580000

Reexamination Certificate

active

07897595

ABSTRACT:
The present invention relates to pyridoazepine derivatives that act as 5-HT ligands, e.g., 5-HT2C. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.

REFERENCES:
patent: 3987047 (1976-10-01), Griss et al.
patent: 4409220 (1983-10-01), Hurnaus et al.
patent: 6953787 (2005-10-01), Smith et al.
patent: 2007/0060568 (2007-03-01), Smith et al.
patent: 2007/0191259 (2007-08-01), Aiwerx et al.
patent: 2357253 (1975-05-01), None
patent: 2442097 (1976-03-01), None
patent: 2521544 (1976-12-01), None
patent: 2617101 (1977-11-01), None
patent: 2638828 (1978-03-01), None
patent: 2722416 (1978-11-01), None
patent: WO 97/48702 (1997-12-01), None
patent: WO 03/057213 (2003-07-01), None
patent: WO 03/086306 (2003-10-01), None
patent: WO 03/095428 (2003-11-01), None
patent: WO 2004/031181 (2004-04-01), None
patent: WO 2005/003096 (2005-01-01), None
patent: WO 2005/019179 (2005-03-01), None
patent: WO 2005/019180 (2005-03-01), None
patent: WO 2005/025576 (2005-03-01), None
patent: WO 2005/042490 (2005-05-01), None
patent: WO 2005/042491 (2005-05-01), None
patent: WO 2005/051398 (2005-06-01), None
patent: WO 2005/051399 (2005-06-01), None
patent: WO 2005/082859 (2005-09-01), None
patent: WO 2006/004931 (2006-01-01), None
patent: WO 2006/044762 (2006-04-01), None
patent: WO 2006/069363 (2006-06-01), None
patent: WO 2006/071740 (2006-07-01), None
patent: WO 2007/025144 (2007-03-01), None
patent: WO 2007/028082 (2007-03-01), None
patent: WO 2007/028083 (2007-03-01), None
patent: WO 2007/028131 (2007-03-01), None
patent: WO 2007/028132 (2007-03-01), None
patent: WO 2008/009125 (2008-01-01), None
International Preliminary Report on Patentability for PCT/US2007/069552, mailed Dec. 11, 2008.
Glennon et al., α4β2 nACh Receptor Pharmacophore Models, 2004, Bioorg. Med. Chem. Lett., vol. 14, pp. 1841-1844.
International Search Report for PCT/US07/69552, mailed Nov. 7 2007.
Written Opinion of the International Search Authority for PCT/US07/69552, mailed Nov. 7, 2007.
Dunlop et al., Pharmacological Profile of the 5-HT2cReceptor Agonist WAY-163909; Therapeutic Potential in Multiple Indications. CNS Drug Reviews, 2006, vol. 12, No. 3-4, 167-177.
Garzya et al., Studies Towards the Identification of a New Generation of Atypical Antipsychotic Agents. Bioorg. & Med. Chem. Lett., 17(2007) 400-405.
Jandacek, APD-356, Curr. Op. Invest. Drugs 2005, 6(10), 1051-56.
McKenna et al., Novel Tacrine Analogues for Potential Use Against Alzheimer's Disease: Potent and Selective Acetylcholinesterase Inhibitors and 5-HT Uptake Inhibitors. J. Med. Chem. 1997, 40, 3516-3523.
Negash et al., Further Definition of the D1Dopamine Receptor Pharmacophore: Synthesis oftrans-6,6a,7,8,9,13b-Hexahydro-5H-benzo[d]naphtha[2,1-b]azepines as Rigid Analogues of β-Phenyldopamine. J. Med. Chem. 1997, 49, 2140-2147.
Nilsson, 5-Hydroxytryptamine 2C (5-HT2c) Receptor Agonists as Potential Antiobesity Agents. J. Med. Chem. Published on web Jun. 17, 2006, A-L.
Smith et al., Discovery and SAR of New Benzazepines as Potent and Selective 5-HT2cReceptor Agonists for the Treatment of Obesity. Bioorg. & Med. Chem. Lett., 15 (2005) 1467-1470.
Smith et al., The Potential Use of Selective 5-HT2cAgonists in Treating Obesity. Expert Opin. Investig. Drugs (2006) 15(3):257-266.
Weinstock et al., Synthesis, Conformation, and Dopaminergic Activity of 5,6-Ethano-bridged Derivatives of Selective Dopaminergic 3-Benzazepines. J. Med. Chem. 1987, 30, 1303-1308.
ADP-356, thomsonpharma.com, Jan. 12, 2006.
Drug Report for : Locaserin, Thomson Current Drugs, IDDB3, Sep. 17, 2006.
Locaserin, thompsonpharma.com, Feb. 22, 2007.

Affiliated with

Also associated with

Rating

Pyridoazepine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyridoazepine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyridoazepine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2775659