Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agen

Details Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agen Pyrido[3,4-B]indole carboxamide derivatives as serotonergic agen

1994-10-20

1995-08-08

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 87, A61K 3144, C07D47104

Patent

active

054399157

ABSTRACT:
The compound of the formula: ##STR1## where R.sub.1 and R.sub.7 are independently hydrogen, fluorine, chlorine, bromine, iodine, trifluoromethyl, cyano, nitro, CO.sub.2 H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.10 alkenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.8 cycloalkyl, cycloalkylalkyl, C.sub.3 -C.sub.8 cycloalkyloxy, C.sub.2 -C.sub.7 alkylcarbonyl, C.sub.2 -C.sub.7 alkylcarbonyloxy, C.sub.2 -C.sub.7 alkoxycarbonyl, mono or di-alkylaminocarbonyl, tetrazolyl,-OH,-(CH.sub.2).sub.1-6 OH, -SH, -NH.sub.2 or-(CH.sub.2).sub.1-6 NR.sub.8 R.sub.9 where R.sub.8 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.7 alkylcarbonyl, C.sub.2 -C.sub.7 alkoxycarbonyl and R.sub.9 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.2 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.3 and R.sub.4 are hydrogen or taken together with the carbon atoms to which they are attached form a double bond; R.sub.5 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.6 is C.sub. 1 -C.sub.12 alkyl, C.sub.3 to C.sub.8 cycloalkyl, cycloalkylalkyl, or C.sub.6 to C.sub.12 bicyclic or C.sub.9 to C.sub.14 tricyclic alkyl; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4719211 (1988-01-01), Abou-Gharbia
patent: 4988814 (1991-01-01), Abou-Gharbia et al.
VanderMaelen et al., European Journal of Pharmacology, 129, pp. 123-130, (1986).

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