Pyrido[3,2-e]pyrazines, their use as inhibitors of...

Details Pyrido[3,2-e]pyrazines, their use as inhibitors of... Pyrido[3,2-e]pyrazines, their use as inhibitors of...

2007-05-24

2009-06-23

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S346000

Reexamination Certificate

active

07550465

ABSTRACT:
The invention relates to pyrido[3,2-e]pyrazines, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 10, as active compounds for treating diseases of mammals including a human which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 10 activity in the central nervous system. More particularly, the invention relates to the treatment of neurologic and psychiatric disorders, for example psychosis and disorders comprising cognitive deficits as symptoms.

REFERENCES:
patent: 2003/0032579 (2003-02-01), Lebel
patent: 1 250 923 (2002-10-01), None
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker (Modern Pharmaceutics) Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.

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