Pyrido[2,3-d]pyrimidine compounds useful as intermediates

Details Pyrido[2,3-d]pyrimidine compounds useful as intermediates Pyrido[2,3-d]pyrimidine compounds useful as intermediates

1992-02-04

1993-06-29

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D47104

Patent

active

052236200

ABSTRACT:
New fused pyrimidines of the general formula (I): ##STR1## wherein the ring A is a pyridine ring which may be hydrogenated or a benzene ring which may be hydrogenated, X is an amino group or a hydroxyl group, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, fluorine or a lower alkyl group, and --COOR.sup.5 and --COOR.sup.6 are independently a carboxyl group which may be esterified, and salts thereof have excellent anti-tumor effects, and they can be produced by the following reaction scheme: ##STR2## in which A is, X, R.sup.1 to R.sup.4, --COOR.sup.5 have the above meanings.

REFERENCES:
patent: 4460591 (1984-07-01), DeGraw et al.
patent: 4684653 (1987-08-01), Taylor et al.
patent: 4725687 (1988-02-01), Piper et al.
Bianchi, "1-Pharmacology," Chemical Abstracts, vol. 103, No. 1, pp. 607, 668 (1985).
Chemical Abstracts vol. 103, No. 1, Abstract 6676, p. 607, 1985, Taylor et al.
Hynes et al., "Synthesis of Quinazoline Analogs of Isofolic Acid," Journal of Medicinal Chemistry, vol. 18, No. 6, pp. 632-634 (1975).
Taylor et al., "Synthesis of the Antileukemic Agents 5, . . . ", Journal of Medicinal Chemistry, vol. 28, pp. 914-921 (1985).

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