Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine...

Details Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine... Pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine...

2006-07-25

2006-07-25

Lewis, Patrick (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S043000, C514S046000, C514S047000, C514S048000, C536S022100, C536S026100, C536S026700

Reexamination Certificate

active

07081449

ABSTRACT:
A purine nucleoside analog includes a pyrido[2,3-d]pyrimidine or a pyrimido[4,5-d]pyrimidine and further has a sugar moiety that is optionally modified at the C2′, C3′, C4′ and/or C5′ position. Particularly contemplated compounds also include prodrug forms of the purine nucleoside analogs, and both purine nucleoside analogs and the corresponding prodrugs are employed in the reduction of growth of neoplastic cells.

REFERENCES:
patent: 3423398 (1969-01-01), Koppaka et al.
Wang et al. J. Med. Chem. (2000), vol. 43, pp. 3704-3713.
Pyridopyrimidines.7. Ribonucleosides Structurally Related to the Antitumor Antibiotic Sangivamycin, Gary L. Anderson et al., 1976, et al., J. Org. Chem., vol. 42, No. 6. 1977, pp. 997-1000.
Pyrido[2,3-d]pyrimidines.III Synthesis of Some 8-(β-D-Ribofuranosyl)pyrido[2,3-d]pyrimidines Structurally Related to the Antibiotic Sangivamycin1, Boshra H. Rizkalla et al., J. Org. Chem., vol. 37, No. 25, 1972, pp. 3980-3985.

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