Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1989-05-11
1991-02-26
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544236, 546116, A61K 3150, C07D47104
Patent
active
049962043
ABSTRACT:
A series of novel 6-substituted-5-oxo-6H-pyrido[2,3-d]pyridazine-8-ylacetic acid and 7-substituted-8-oxo-7H-pyrido[2,3-d]pyridazine-5-ylacetic acid compounds have been prepared, including their C.sub.1 -C.sub.6 alkyl ester derivatives, as well as the base salts of said acids with pharmacologically acceptable cations. Typical member compounds include those acids wherein the ring substitutent is always attached to the available ring-nitrogen atom and is either a lower aralkyl group or a lower heteroaralkyl group. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4209527 (1980-06-01), Sarges
patent: 4251528 (1981-02-01), Brittain et al.
Mylari et al., Chemical Abstracts, vol. 107, No. 176055 (1987) (Abstract for EP No. 222576, 5/20/87).
Ormaza, Chemical Abstracts, vol. 106, No. 67338 (1987)(Abstract for ES No. 548146, 3/16/86).
Mylari Banavara L.
Zembrowski William J.
Bernjardt E.
Ginsburg Paul H.
Pfizer Inc.
Richardson Peter C.
Shah Mukund J.
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