Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -t

Details Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -t Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -t

1994-08-17

1996-08-20

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540488, 546292, A61K 3155, C07D51304, C07D49804

Patent

active

055479510

ABSTRACT:
Compounds of the class of pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and -thiones, having the following general structural formula ##STR1## wherein either X or Z is sulfur and the other substituent is oxygen or both X and Z are sulfur, which are inhibitors of HIV-1 reverse transcriptase and useful in the treatment of HIV-1 infection. An exemplary compound is 2-chloro-5-(methylthioethyl)pyrido[2,3-b][1,4]benzoxazepin-6(5H)one.

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