Pyrido[1,2-a]pyrimidinone derivatives

Details Pyrido[1,2-a]pyrimidinone derivatives Pyrido[1,2-a]pyrimidinone derivatives

1975-06-05

1976-06-01

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260251A, 424251, C07D47104

Patent

active

039608638

ABSTRACT:
3-[2-(4-PHENYL-1-PIPERAZINYL)ETHYL]-4H-pyrido[1,2-a]pyrimidin-4-one derivatives have central nervous depressant and hypotensive activities and are useful as major tranquillizers.
The compounds can be prepared by (a) reacting 2-methyl-3-halogeno (or arylsulfonyloxy or alkylsulfonyloxy)ethyl-4H-pyrido[1,2-a]pyrimidin-4-one derivative with 1-phenylpiperazine derivative or (b) reacting an aminopyridine with 2-[2-(4-phenyl-1-piperazinyl)ethyl]-acetoacetic acid ester.

REFERENCES:
patent: 3299067 (1967-01-01), Regnier et al.
patent: 3491097 (1970-01-01), Koppe et al.
patent: 3808212 (1974-04-01), Renth et al.
patent: 3887557 (1975-06-01), Minami et al.

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