Pyridinyl substituted benzimidazoles and quinoxalines

Details Pyridinyl substituted benzimidazoles and quinoxalines Pyridinyl substituted benzimidazoles and quinoxalines

1982-08-13

1984-02-07

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546271, 424250, 424263, C07D40112, C07D40106, A61K 3144

Patent

active

044305028

ABSTRACT:
The present invention provides novel pyridinyl-benzimidazoles and quinoxalines which are useful as thromboxane A.sub.2 (TXA.sub.2) synthetase inhibitors and as such represent potent pharmacological agents.

REFERENCES:
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patent: 4032536 (1977-06-01), Raeymaekers et al.
patent: 4112224 (1978-09-01), Bundy
patent: 4259338 (1981-03-01), Paioni et al.
patent: 4331671 (1982-05-01), Lesher
patent: 4335132 (1982-06-01), Lesher
D. Harris et al., Advances in Prostaglandin and Thromboxane Research, 6:437 (1980).
T. Miyamoto et al., Advances in Prostaglandin and Thromboxane Research, 6:443 (1980).
H. Tai et al., Advances in Prostaglandin and Thromboxane Research, 6:447 (1980).
Dol'nikov et al., Chem. Abs., vol. 76, 1972, 135663h.

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