Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-09-09
1992-12-08
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546156, A61K 3147, C07D40104
Patent
active
051698536
ABSTRACT:
Fluorinated 1- cyclopropyl-7-(substituted-pyridinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxy lic acids of the formula ##STR1## wherein R is hydrogen, R' and R" are hydrogen or fluoro, and Z is 3- or 4-pyridinyl substituted by alkyl groups or substituted alkyl groups, are superior antibacterial agents. They are prepared via a coupling reaction between the corresponding esters (R=alkyl) having a halo group in the 7-position and a substituted (trialkylstannyl)-pyridine.
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patent: 4636506 (1987-01-01), Gilligan et al.
patent: 4670444 (1987-06-01), Grohe et al.
Himmler et al., Chemical Abstracts, vol. 112, No. 216720 (Abstract for DE 3816119, Nov. 23, 1989).
Daum Sol J.
Lesher George Y.
Reuman Michael
Singh Baldev
Bernhardt E.
DuPont Paul E.
Shah Mukund J.
Sterling Drug Inc.
Stonner Frederik W.
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